Has two career holes-in-one in competitive rounds, both while playing with TOUR player Doug LaBelle II.

Wife Amy is the former president of the PGA TOUR Wives Association, and the two are heavily involved in the Blessings in a Backpack charitable organization, with a mission of sending needy school children home every weekend with nonperishable food they can eat on Saturday and Sunday. The 2015 Mark Wilson Charity Classic, held at Royal Melbourne Country Club outside Chicago, raised $170,000, enough to feed the nearly 600 eligible kids in the two schools the Wilsons sponsor for four years. In addition to PGA TOUR members, celebrities included former Chicago Bears All-Pro linebacker Brian Urlacher and Northwestern University basketball coach Chris Collins.

The Wilsons are also involved with the MACC Fund (Midwest Athletes Against Childhood Cancer), the Amy and Mark Wilson Delta Gamma Lectureship in Values and Ethics at Indiana University, the Western Golf Association Evans Scholars Foundation and The First Tee of Chicago.